The FBI's Portland office said it was investigating an "agent involved shooting" that happened in the city about 2.15pm. According to the Portland Police bureau, officers initially responded to a report of a shooting near a hospital.
A few minutes later, police received information that a man who had been shot was asking for help in a different area a couple of miles away. Officers then responded there and found the two people with apparent gunshot wounds. Officers determined they were injured in the shooting with federal agents, police said.
Their conditions were not immediately known.
The Department of Homeland Security said border patrol agents were conducting a vehicle stop when the driver "weaponized" the vehicle before an officer "fired a defensive shot", the Department of Homeland Security said on X, adding that the vehicle's passenger was the target of the stop.
Council President Elana Pirtle-Guiney said during a Portland city council meeting that Thursday's shooting took place in the eastern part of the city and that two Portlanders were wounded.
"As far as we know both of these individuals are still alive and we are hoping for more positive updates throughout the afternoon," she said.
The shooting comes a day after an Immigration and Customs Enforcement (ICE) officer shot and killed a woman in Minnesota. It escalated tensions in an city that has long had a contentious relationship with President Donald Trump, including Trump's recent, failed effort to deploy National Guard troops in the city.
Minneapolis woman Renee Nicole Good, 37, was shot by an ICE officer as she tried to drive away on a snowy Minneapolis street on Wednesday. The killing has inflamed tensions in the community and is causing friction between state and federal authorities over its investigation.
US President Donald Trump has made a wide-ranging crackdown on crime and immigration in Democratic cities a centrepiece of his second term in office.
He has deployed federal law enforcement officials and National Guard troops to support the operations and has floated the idea of invoking the Insurrection Act to try to stop his opponents from blocking his plans through the courts.
Portland police secured both the scene of the shooting and the area where the wounded people were found pending investigation.
"We are still in the early stages of this incident," said Chief Bob Day. "We understand the heightened emotion and tension many are feeling in the wake of the shooting in Minneapolis, but I am asking the community to remain calm as we work to learn more."
Portland Mayor Keith Wilson and the city council called on US Immigration and Customs Enforcement to end all operations in Oregon's largest city until a full investigation is completed.
"We stand united as elected officials in saying that we cannot sit by while constitutional protections erode and bloodshed mounts," a joint statement said.
"Portland is not a 'training ground' for militarized agents, and the 'full force' threatened by the administration has deadly consequences."
The city officials said "federal militarization undermines effective, community‑based public safety, and it runs counter to the values that define our region. We'll use every legal and legislative tool available to protect our residents' civil and human rights."
They urged residents to show up with "calm and purpose during this difficult time".
"We respond with clarity, unity, and a commitment to justice," the statement said. "We must stand together to protect Portland."
US Senator Jeff Merkley, an Oregon Democrat, urged any protesters to remain peaceful.
"Trump wants to generate riots," he said in a post on the X social media platform. "Don't take the bait."
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