The historic gift has little precedent, with few single charitable commitments in the past 25 years exceeding $US1 billion.
Announced on Tuesday, the Dells believe it's the largest single private commitment made to US children.
Its structure is also unusual. Essentially, it builds on the "Trump Accounts" program, where the US Department of the Treasury will deposit $US1000 into investment accounts it sets up for American children born between January 1, 2025 and December 31, 2028.
The Dells' gift will use the "Trump Accounts" infrastructure to give $US250 to each qualified child under 11.
"We believe that if every child can see a future worth saving for, this program will build something far greater than an account. It will build hope and opportunity and prosperity for generations to come," said Michael Dell, the founder and CEO of Dell Technologies whose estimated net worth is $US148 billion, according to Forbes.
Though the "Trump Accounts" became law as part of the US president's signature legislation in July, the Dells say the accounts will not launch until July 4, 2026.
Michael Dell said they wanted to mark the 250th anniversary of US independence.
"We want these kids to know that not only do their families care, but their communities care, their government, their country cares about them," Susan Dell told The Associated Press.
Under the new law, "Trump Accounts" are available to any American child under 18 with a Social Security number. Account contributions must be invested in an index fund that tracks the overall stock market. When the children turn 18, they can withdraw the funds to put toward their education, to buy a home or to start a business.
The Dells will put money into the accounts of children 10 and younger who live in post codes with a median family income of $US150,000 or less and who won't get the $US1000 seed money from the Treasury.
The Dells hope their gift will encourage families to claim the accounts and deposit more money into it, so it will grow over time along with the stock market.
At the White House, Trump praised the Dells saying their gift was, "truly one of the most generous acts in the history of our country."
Trump said many companies and many of his friends would also be donating, adding "I'll be doing it, too."
