Young, in a statement on his website, criticised the music streaming platform's chief executive officer, Daniel Ek, saying he was the main problem, in the wake of criticism of US podcaster Joe Rogan, who has courted controversy with his views on COVID-19 vaccines and his use of racial slurs.
Spotify hosts the top-rated podcast "The Joe Rogan Experience" podcast.
"In our communication age, misinformation is the problem. Ditch the misinformers," Young said in the statement.
The rock star pulled his content from the streaming platform last month after objecting to his music being played on the same platform as Rogan's podcast, over what Young said was misleading information on vaccines.
Several prominent figures including singer-songwriter Joni Mitchell, guitarist Nils Lofgren and best-selling US professor and author Brene Brown followed suit.
Young also urged people to move their money out of multinational banks JPMorgan Chase & Co, Citigroup Inc , Bank of America Corp and Wells Fargo & Co , calling them "damage causers" for their funding of fossil fuels.
Rogan has apologised for both the racial slurs and the controversy over COVID vaccines.
Young's comments come a day after Ek told his staff that while he condemned the slurs used by Rogan, the company would not be silencing him.
Addressing employees of the music platform, Young said: "I say Daniel Ek is your big problem - not Joe Rogan. Get out of that place before it eats up your soul."
Young also urged fellow musicians and artists to take their output elsewhere.
The platform saw more than $US2 billion wiped off its market value last week amid the uproar over COVID misinformation.
The company has said it would add a "content advisory" to any episode that includes discussion of the coronavirus.Â
