There were no immediate reports of casualties, regional governor Andrei Bocharov was quoted as saying in a Telegram post published on the channel of the local administration.
The post did not specify the damage but said that people living near the depot may have to be relocated.
Ukraine's long-range drone strikes on Russian energy sites aim to deprive the country of the oil export revenue it needs to pursue its full-scale invasion.
Russia wants to cripple the Ukrainian power grid in what officials in Kyiv say is a bid to "weaponise winter" and deny civilians access to heat, light and running water.
Saturday's attack came the day after Russia bombarded Ukraine with hundreds of drones and dozens of missiles overnight into Friday, according to Ukrainian officials, killing at least four people in the capital.
For only the second time in the nearly four-year-old war, it used a powerful new hypersonic missile that struck western Ukraine on Friday.
The intense barrage and the launch of the nuclear-capable Oreshnik missile followed reports of major progress in talks between Ukraine and its allies on how to defend the country from further Russian aggression if a US-led peace deal is struck.
Russia's Defence Ministry said on Saturday that its forces used aviation, drones, missiles and artillery to strike Ukrainian energy facilities and fuel-storage depots on Friday and overnight.
It did not immediately specify the targets or damage.
Overnight into Saturday, Russia struck Ukraine with 121 drones and one Iskander-M ballistic missile, according to the Ukrainian air force.
Ukrainian authorities said 94 drones were shot down.
23°C