Nobody's Girl: A Memoir of Surviving Abuse and Fighting for Justice is scheduled for release on October 21, the publisher Alfred A Knopf confirmed to The Associated Press.
Giuffre, who died by suicide at her farm in Western Australia in April at age 41, had been working on Nobody's Girl with author-journalist Amy Wallace.
They had completed the manuscript for the 400-page book, according to Knopf.
The publisher's statement includes an email from Giuffre to Wallace a few weeks before her death, saying that it was her heartfelt wish that the memoir be released regardless of her circumstances.
"The content of this book is crucial, as it aims to shed light on the systemic failures that allow the trafficking of vulnerable individuals across borders," the email reads.
"It is imperative that the truth is understood and that the issues surrounding this topic are addressed, both for the sake of justice and awareness."
Giuffre had been recovering in hospital, following a serious accident on March 24, Knopf said, and sent the email on April 1.
She died on April 25.
"In the event of my passing, I would like to ensure that NOBODY'S GIRL is still released. I believe it has the potential to impact many lives and foster necessary discussions about these grave injustices," she wrote to Wallace.
In 2023, the New York Post had reported that Giuffre had reached a deal "believed to be worth millions" with an undisclosed publisher.
Knopf spokesperson Todd Doughty said that she initially agreed to a seven-figure contract with Penguin Press, but moved with acquiring editor Emily Cunningham after Knopf hired Cunningham as executive editor last year.
Giuffre had often stated that, in the early 2000s, when she was a teenager, she was caught up in Epstein's sex-trafficking ring and exploited by Britain's Prince Andrew and other influential men.
Epstein was found dead in a New York City jail cell in 2019 in what investigators described as a suicide.
His former girlfriend, Ghislaine Maxwell, was convicted in late 2021 on sex trafficking and other charges.
Andrew had denied Giuffre's allegations.
In 2022, Giuffre and Andrew reached an out-of-court settlement after she had sued him for sexual assault.
Giuffre's name has continued to appear in headlines, even after her death.
In July, President Donald Trump told reporters that Epstein had "stolen" Giuffre from Mar-a-Lago, his private club in Florida, where she once worked.
She had alleged being approached by Maxwell and hired as a masseuse for Epstein. Maxwell has denied Giuffre's allegations.
Knopf Publisher and Editor-in-Chief Jordan Pavlin, in a statement, called Nobody's Girl a "raw and shocking" journey and "the story of a fierce spirit struggling to break free".
Giuffre's time with Epstein is well documented, although her accounts have been challenged.
She had acknowledged getting details wrong, errors she attributed to trying to recall events from years ago.
"Nobody's Girl was both vigorously fact-checked and legally vetted," the Knopf statement reads.
Giuffre's co-author on her memoir, Wallace, is an award-winning magazine and newspaper reporter whose work has appeared in The New York Times and the Los Angeles Times, among other publications.
She has also collaborated on two previous books, Pixar co-founder Ed Catmull's Creativity, Inc. and former General Electric CEO Jeff Immelt's Hot Seat.
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