Their long statement sought to push back against what it said were inaccurate and unsympathetic portrayals of Blair, 54, and the Delta flight from Los Angeles to New York on Sunday that led to her first arrest.
"Selma Blair experienced a medical emergency on the flight," the statement said on Friday.
"There was no attempt to open the door of the aircraft. Selma did not intend to harm anyone."
A previous statement along with her lawyer's remarks in court had said briefly that a medical emergency was behind all that happened, but the new statement gave a more detailed defence.
Blair has multiple sclerosis, and without specifying she had done so, the statement said it was "outrageous" that anyone would suggest she did not.
"Her diagnosis has been public since 2018," the statement said.
"What Selma has been able to do physically in the years since is nothing short of a miracle. She still has bad days, and she lives with pain daily.
"Selma also has pseudobulbar affect, a neurological condition secondary to her MS, which bears directly on how a medical episode presents to people who do not know her.
"For the same reason, she travels with a service dog who doesn't leave her side, and the authorities took her dog from her."
Blair was accused of injuring two flight attendants on the plane bound for John F Kennedy Airport, then kicking a police officer taking her to the hospital and kicking a nurse once she got there, according to a statement from the Port Authority of New York and New Jersey.
She pleaded not guilty on Monday to two counts of assault on state charges involving the officer and the nurse, and a judge issued a protective order for them.
She is free on bail, and her next court date is in January.
The FBI also issued Blair a notice charging her with assault related to her actions aboard the aircraft.
Blair's major film roles have included 1999's Cruel Intentions, 2001's Legally Blonde and 2004's Hellboy.
