The mining magnate said a commitment from government to channel funds back to the regions could see medical facilities and infrastructure upgraded.
"Frankly, we should have the best equipped and most luxurious hospitals in Newman, Tom Price Dampier, Cape Lambert, Port Hedland and other mining towns thanks to the revenue we create in the Pilbara, and similarly, in other mining areas," she told a News Corp bush summit in Perth.
"Ditto, see 24 hour, 365 days a year airstrips so the better equipped and fastest Royal Flying Doctor planes can always arrive.
"Us and our people in the outback would then be more safe."
Mrs Rinehart advocated for special economic zones to be created, along with tax cuts for those working in northern Australia.
She said limits on work hours for pensioners and veterans before government payments are cut off should also be removed, in order for more jobs to be filled in regional areas.
"Just imagine the smiles when we can finally fill those jobs in the bush and see hospitals and health centre hours and effectiveness improved.
"If we could cut some of the paperwork and the regulations here, we would find a lot of Aussies who would actually like to work very much as well, they're just restricted by government."
Mrs Rinehart said the mining industry would be able to afford the transition to net zero but other sectors, including agriculture would face a tougher time meeting requirements.
She called on the federal government to meet the costs involved or waive it altogether.
"They want to implement the net zero.
"Otherwise, most farmers and others in agriculture, you know, be it the orchardists and others, cannot afford net zero."
Farmers would have to leave the industry and Aussies would see huge price increases for food, along with fresh food shortages, Mrs Rinehart warned.
She also reiterated support for nuclear energy to be implemented in the country.
"Let's not upset many farmers with bird killing wind generators and massive solar panel stretches and bring on clean safe nuclear energy."
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