The 17-year-old boy suffered life-threatening injuries after an alleged altercation at the Islamic College of Brisbane on Tuesday.
Police say the incident involved two teenage boys who knew each other at the school at Karawatha in Brisbane's south about 11.45am.
It will be alleged a 16-year-old boy stabbed the 17-year-old, from Logan, with a small knife, causing life-threatening injuries.
The injured boy was treated at the scene before being rushed to Princess Alexandra Hospital.
Police allege the 16-year-old left the scene and was later found in a vehicle about 5km away.
He is expected to face Richlands Children's Court on Wednesday, charged with acts intended to maim, disfigure or disable, and unlawful possession of weapons.
The alleged attack is the second stabbing at a Queensland high school in as many days.
In a message to parents and carers posted on social media, the Islamic College of Brisbane said the injured student was ''receiving medical care'' and ''recovering'', with no ongoing risk to students or staff.
The school acknowledged the incident had been ''distressing'' for the community and said extra wellbeing staff and counsellors would be on campus, with classes to operate as normal on Wednesday.
The statement also flagged that several parents had asked why communication during the incident was limited and urged families not to comment on social media speculation, warning that misinformation could cause ''unnecessary distress''.
''During emergency situations such as lockdowns and major incidents, the college follows established emergency management protocols and works closely with Queensland Police and other emergency services,'' the social media statement said.
''All communications during these events are made in consultation with the relevant authorities to ensure they do not compromise the safety of students, staff, emergency responders, or the integrity of the police investigation.
''Parents were informed as soon as the college received clearance from the relevant authorities to communicate.''
The college said the safety and wellbeing of students would ''always remain our first priority'' and pledged to keep families updated as verified information became available.
The alleged stabbing came a day after a separate incident at Trinity Bay State High School in Cairns.
There, a 15-year-old boy was taken to hospital in a stable condition after suffering abdominal wounds in an altercation about 11.40am on Monday.
Another 15-year-old boy allegedly fled on foot and was found nearby about half an hour later.
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