People will no longer need to check in at cafes, supermarkets, shopping centres, schools, hospitals and aged care homes from 6pm on Friday.
But the codes will still have to be used at bars, pubs, nightclubs and the casino.
Premier Peter Gutwein says the state is transitioning to living with COVID-19, with schools and businesses remaining open.
"We're getting on top of this and I think it's really positive at the moment," he told reporters.
There have been more than 142 million check-ins at 56,000 venues across the stater, with the Check in TAS app to remain functional so people can prove their vaccination status if required.
Mr Gutwein said QR codes and other restrictions such as masks would be further reviewed in the next two-to-four weeks.
The QR code restrictions have been lifted despite outbreaks in 15 schools across the state, with 226 students infected, about a week after some 60,000 public school students returned to the classroom for term one.
But Mr Gutwein said there had been little disruption to overall learning, and case numbers in school aged cohorts were in fact no higher than before students had returned to school.
Meanwhile, Tasmania is also closing four of its quarantine hotels, leaving only the Ibis in Hobart, the Peppers Seaport in Launceston and the Sunrise in Devonport.
There are 17 people currently quarantining in the hotels.
More than 96 per cent of Tasmanians aged 12 and above have been fully vaccinated, with almost 61 per cent of children aged five to 11 having had at least one dose.
Deliveries of the newly approved Novovax jab are beginning from Friday, with 37 pharmacies and GPs to offer the vaccine.
Mr Gutwein said about 850 people in Tasmania had not received a first dose and urged them to line up for the Novovax jab.
It comes as as Tasmania records 623 new COVID-19 infections, down more than 50 from the previous day's tally.
The cases included 138 positive results from PCR tests and 485 from rapid antigen tests, the health department said on Friday, with the state now dealing with 3406 active cases.
The number of people in hospital with the virus has dropped to 11, down from 16 on Thursday.
Seven of those patients are being treated specifically for COVID-19, with the other four being treated for unrelated medical conditions.
Two patients are in intensive care.
Tasmania has recorded 10 coronavirus deaths since reopening borders on December 15 and a total of 23 since the beginning of the pandemic.
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